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mouse genome-scale crispr knockout library gecko v2  (Genechem)

 
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    Genechem mouse genome-scale crispr knockout library gecko v2
    Mouse Genome Scale Crispr Knockout Library Gecko V2, supplied by Genechem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+genome-scale+crispr+knockout+library+gecko+v2/mouse+genome+scale+crispr+knockout+library+gecko+v2/pmc11671903__gutjnl___74___1___s001-19-1-10
    Average 90 stars, based on 1 article reviews
    mouse genome-scale crispr knockout library gecko v2 - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    CRISPR:

    Article Title: Nuclear translocation of plasma membrane protein ADCY7 potentiates T cell-mediated antitumour immunity in HCC
    Article Snippet: The mouse genome-scale CRISPR knockout library (GeCKO v2, purchased from Genechem Co.,Ltd., Shanghai, China) containing 130,209 sgRNAs targeting 20,611 genes1 was packed into lentiviral particles and transduced into Hepa1-6 cells at a low multiplicity of infection (MOI < 0.3).

    Knock-Out:

    Article Title: Nuclear translocation of plasma membrane protein ADCY7 potentiates T cell-mediated antitumour immunity in HCC
    Article Snippet: The mouse genome-scale CRISPR knockout library (GeCKO v2, purchased from Genechem Co.,Ltd., Shanghai, China) containing 130,209 sgRNAs targeting 20,611 genes1 was packed into lentiviral particles and transduced into Hepa1-6 cells at a low multiplicity of infection (MOI < 0.3).

    Infection:

    Article Title: Nuclear translocation of plasma membrane protein ADCY7 potentiates T cell-mediated antitumour immunity in HCC
    Article Snippet: The mouse genome-scale CRISPR knockout library (GeCKO v2, purchased from Genechem Co.,Ltd., Shanghai, China) containing 130,209 sgRNAs targeting 20,611 genes1 was packed into lentiviral particles and transduced into Hepa1-6 cells at a low multiplicity of infection (MOI < 0.3).



    Similar Products

    mouse genome-scale crispr knockout library gecko v2  (Genechem)
    90
    Genechem mouse genome-scale crispr knockout library gecko v2
    Mouse Genome Scale Crispr Knockout Library Gecko V2, supplied by Genechem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+genome-scale+crispr+knockout+library+gecko+v2/mouse+genome+scale+crispr+knockout+library+gecko+v2/pmc11671903__gutjnl___74___1___s001-19-1-10
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    mouse genome scale crispr knockout library  (Addgene inc)
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    Addgene inc mouse genome scale crispr knockout library
    Lentiviral delivery of the <t>CRISPR</t> <t>knockout</t> library identifies Cul3 as a suppressor of CC in SPC mice. (A) Outline of tail vein injection of lentivirus-mediated CRISPR knockout library. (B) Livers injected with the CRISPR knockout library develop tumors at 3-4 months, while the control livers are normal. (C) Summary of tumor numbers in each mouse. (D) Histology analysis of tumors induced by the CRISPR knockout library. AE1 indicates cholangiocytes and Hep Par1 indicates hepatocytes. PCNA represents cell proliferation. (E) Plot shows the average of sgRNA enrichment measured by high-throughput sequencing. (F) Outline of hydrodynamic tail vein injection of sgRNA. (G) Up panel: Representative images of the livers injected with sgRNAs targeting Smad4, Trp53 and Cul3. Down panel: Immunostaining of paraffin sections show the phenotype of CC. (H) Statistics of the tumor number, liver weight and the ratio of the liver weight to body weight (LW/BW).
    Mouse Genome Scale Crispr Knockout Library, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    mouse genome scale crispr knockout gecko v2 0 pooled library  (Addgene inc)
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    Addgene inc mouse genome scale crispr knockout gecko v2 0 pooled library
    Lentiviral delivery of the <t>CRISPR</t> <t>knockout</t> library identifies Cul3 as a suppressor of CC in SPC mice. (A) Outline of tail vein injection of lentivirus-mediated CRISPR knockout library. (B) Livers injected with the CRISPR knockout library develop tumors at 3-4 months, while the control livers are normal. (C) Summary of tumor numbers in each mouse. (D) Histology analysis of tumors induced by the CRISPR knockout library. AE1 indicates cholangiocytes and Hep Par1 indicates hepatocytes. PCNA represents cell proliferation. (E) Plot shows the average of sgRNA enrichment measured by high-throughput sequencing. (F) Outline of hydrodynamic tail vein injection of sgRNA. (G) Up panel: Representative images of the livers injected with sgRNAs targeting Smad4, Trp53 and Cul3. Down panel: Immunostaining of paraffin sections show the phenotype of CC. (H) Statistics of the tumor number, liver weight and the ratio of the liver weight to body weight (LW/BW).
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    Image Search Results


    Lentiviral delivery of the CRISPR knockout library identifies Cul3 as a suppressor of CC in SPC mice. (A) Outline of tail vein injection of lentivirus-mediated CRISPR knockout library. (B) Livers injected with the CRISPR knockout library develop tumors at 3-4 months, while the control livers are normal. (C) Summary of tumor numbers in each mouse. (D) Histology analysis of tumors induced by the CRISPR knockout library. AE1 indicates cholangiocytes and Hep Par1 indicates hepatocytes. PCNA represents cell proliferation. (E) Plot shows the average of sgRNA enrichment measured by high-throughput sequencing. (F) Outline of hydrodynamic tail vein injection of sgRNA. (G) Up panel: Representative images of the livers injected with sgRNAs targeting Smad4, Trp53 and Cul3. Down panel: Immunostaining of paraffin sections show the phenotype of CC. (H) Statistics of the tumor number, liver weight and the ratio of the liver weight to body weight (LW/BW).

    Journal: International Journal of Biological Sciences

    Article Title: Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice

    doi: 10.7150/ijbs.67379

    Figure Lengend Snippet: Lentiviral delivery of the CRISPR knockout library identifies Cul3 as a suppressor of CC in SPC mice. (A) Outline of tail vein injection of lentivirus-mediated CRISPR knockout library. (B) Livers injected with the CRISPR knockout library develop tumors at 3-4 months, while the control livers are normal. (C) Summary of tumor numbers in each mouse. (D) Histology analysis of tumors induced by the CRISPR knockout library. AE1 indicates cholangiocytes and Hep Par1 indicates hepatocytes. PCNA represents cell proliferation. (E) Plot shows the average of sgRNA enrichment measured by high-throughput sequencing. (F) Outline of hydrodynamic tail vein injection of sgRNA. (G) Up panel: Representative images of the livers injected with sgRNAs targeting Smad4, Trp53 and Cul3. Down panel: Immunostaining of paraffin sections show the phenotype of CC. (H) Statistics of the tumor number, liver weight and the ratio of the liver weight to body weight (LW/BW).

    Article Snippet: The following vectors were obtained from Addgene: pCDH-EF1-Luc2-P2A-copGFP (GFP-Luc, #72485), PX330 (#42230), lenti-CRISPR v2 (#52961) and the mouse genome-scale CRISPR knockout library (#1000000052).

    Techniques: CRISPR, Knock-Out, Injection, Next-Generation Sequencing, Immunostaining